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First-line approaches recommended by NICE and the NHS include: Dietary modification a balanced, calorie-reduced diet tailored to individual needs, with guidance from a registered dietitian where appropriate Increased physical activity at least 150 minutes of moderate-intensity aerobic activity per week for adults, in line with the UK Chief Medical Officers' physical activity guidelines Behavioural interventions cognitive behavioural therapy (CBT)-based programmes, group support, and self-monitoring strategies For individuals with a BMI of 30 kg/m or above (or 27.5 kg/m in certain ethnic groups), pharmacological treatment may be considered alongside lifestyle interventions, subject to clinical assessment and specific eligibility criteria: Orlistat reduces dietary fat absorption and is available via GP prescription
Because it is modeled after a naturally occurring gastric protein, it is generally well-tolerated by the body
INCI Nomenclature: Glutathione
Fineman MS, Koda JE, Shen LZ, Strobel SA, Maggs DG, Weyer C, et al
The fundamental mechanism of action involves mimicking the physiological effects of endogenous GLP-1, which is secreted by intestinal L-cells in response to food intake
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