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A., and Lenzi, A
This regulatory status means long-term human safety data remains limited compared to FDA-approved drugs
Its gentle profile makes it popular for lean-muscle preservation during calorie deficits
IGF1R activation triggers autophosphorylation of tyrosine residues, recruiting IRS-1, activating PI3K, which converts PIP2 to PIP3, activating Akt (also called PKB), which phosphorylates and activates mTORC1
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