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For instance, SGLT2 inhibitors may be added if first-line therapies such as diet and lifestyle changes plus metformin are insufficient

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Abstract Background Bariatric surgery (BS) is the most effective treatment for severe obesity, but a significant proportion of patients experience insufficient weight loss (IWL) or weight regain

The best you can do is do nothing, the doctor said

While the results from studies using native OXM in rodents and humans were promising, the short half-life in vivo and the large amount of peptide required to produce an effect made it a poor choice as a treatment in humans