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Clinical trials have demonstrated a 65 percent reduction in vertebral fracture risk and a 35 to 53 percent reduction in non-vertebral fracture risk after 20 months of treatment at 20 micrograms per day
Choline Supplementation Protects against Liver Damage by Normalizing Cholesterol Metabolism in Pemt/Ldlr Knockout Mice Fed a High-Fat Diet
These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism
2a, b (Supplementary Table 1)
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