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doi: 10.1113/jfisiol.2013.255364
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A double-blind RCT (n=150) in patients receiving sagopilone chemotherapy showed no reduction in CIPN incidence with LC, although a slight decrease in severity was observed in ovarian cancer patients (not in prostate cancer patients)
Moreover, baseline LBP and sCD14 levels were similar in patients with normal (2/3 of patients) and increased intestinal permeability (urinary 51 Cr-EDTA excretion), highlighting again that bacterial translocation is not a paracellular phenomenon and that one should be careful of connecting clinical outcomes to paracellular permeability tests (149)
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