do doctors recommend glp 1 GLP-1 Intolerance and Endoscopic Sleeve Options Compounded GLP-1s: Why doctors worry

But with that caveat, we should be studying how these people behave, rather than what theyre telling us, added Prof

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[5] [11] Clinical trials have demonstrated significant weight loss with these medicationstypically 15% with semaglutide 2.4mg (Wegovy) and 5-8% with liraglutide 3.0mg (Saxenda) over 68 weekswhen used alongside dietary changes and physical activity advice

Each compound is dosed once weekly and titrated slowly

Messer says, the amount of weight loss well see clinically with retatrutide will probably exceed what researchers saw in the trial. Some doctors tell me they expect the drug to outperform even bariatric surgery, leading to more weight loss in less time