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3 Nutritional Deficits: A Predictable Outcome of Caloric Restriction Sustained low energy intake inevitably creates a landscape where nutrient gaps are nearly unavoidable, particularly against the backdrop of already suboptimal baseline diets

While the physiological importance of glutathione is undisputed, supplementing it has historically presented a massive pharmacological challenge

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Gastrointestinal adverse effects, initially viewed as limiting, were ultimately managed through dose titration and formulation design