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Data shows intranasal administration provides convenience, rapid onset without requiring reconstitution, and eliminates the common problems of injection-related pain and site reactions
The DiRECT trial showcased the restoration of pancreatic volume and structure through MRI scans post dietary interventions, indicating beta-cell recuperation after significant weight reduction
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However, semaglutide has stronger cardiovascular outcome data (SELECT trial) and may be preferable for patients with cardiovascular history or those who prefer an oral option
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