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Anti-cancer activity of nitrones and observations on mechanism of action

The medication is also FDA-approved for treating heart failure in adults with Type 2 diabetes and heart disease

Buchner A, Hansen LS: Melanotic macule of the oral mucosa

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Its cardiovascular safety in patients with cardiovascular disease or high cardiovascular risk was demonstrated in the aforementioned PIONEER-6 study.62 In the PIONEER 5 study, in patients with CKD stage 3, it was evaluated the efficacy and safety of a 14 mg dose, resulting superior to placebo in terms of reduction of HbA1c (-0.8% vs