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At standard doses, copper toxicity from GHK-CU is extremely unlikely
Mechanistically, it acts as a ghrelin mimetic, binding the growth hormone secretagogue receptor (GHS-R1a) the receptor for the endogenous peptide ghrelin, expressed in the pituitary and hypothalamus
This isn't an immediate switch-off but more of a slow adjustment back to how things were, meaning any improvements in skin texture and firmness gained during use might lessen over time
10.1210/endo.136.8.7628407 177 RobertsV
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