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Fat tissue stores environmental toxins, heavy metals, and lipophilic chemicals accumulated over years

PMID: 12851303 Reported G s / cAMP signalling cAMP elevation via class A GPCR coupling Tao (Endocr Rev 2010) reviewed melanocortin-4 receptor pharmacology, summarizing studies on the MC4R, from its cloning and tissue distribution to its physiological roles across multiple body systems

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Though human studies are lacking, preclinical trials support its potential in treating fractures