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In short, the gut microbiota influences brain function via the regulation of neurotransmitters and neurotrophic factors, maintenance of intestinal barrier and tight junction integrity, activation of enteric sensory afferents, production of bacterial metabolites, and modulation of mucosal immune responses [22]
After delivery by intraperitoneal injection, a single 50 mg kg 1 dose of ( S )-dHTC1 produced a maximal plasma concentration ( C max ) of nearly 50 M within 20 min (2.5 M adjusted for 94.9% plasma protein binding, PPB) (Fig
