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In an intervention study, however, it is possible that medullary tissue could be affected differently than cortical tissue, and that ADC consequently may result in an incorrect estimate of cortical changes

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The models have been used to predict pharmacokinetics in special populations, including those with hepatic or renal impairment, as well as in disease states such as type 2 diabetes and obesity

A causative role of oxidative stress in ALD is supported by several lines of evidence 27