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This rebound effect occurs because the amylin receptor system, having adapted to sustained agonism, temporarily overcompensates when that stimulation is removed

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It is a very important antioxidant, participates in detoxification of certain drugs, toxic environmental chemicals, protects against lipid peroxidation and electrophiles, has antiviral effects, is involved in the biosynthesis of DNA, proteins, and leukotrienes, cell proliferation, apoptosis, neurotransmission, and neuromodulation

Metformin rescues the myocardium from doxorubicin-induced energy starvation and mitochondrial damage in rats