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Myostatin primarily mediates the upregulation of MAFbx gene expression through the transcription factors Smad2/3, thereby promoting protein degradation (140,141)
Blumberg: People using GLP-1 medications eat significantly less than they did before treatment, creating a deficit not only in calories but also in essential macronutrients like protein and micronutrients, such as vitamins and minerals
IFSO consensus on definitions and clinical practice guidelines for obesity management-an international Delphi study
Good news is that it's now been shown that after 1 year we can space out treatment (Q2W instead of QW) or replace it with oral one (more tolerated by patients) and keep (most of) the weight loss.
J., & Castell, M
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