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In the presence of GSH, GPX4 mediates the conversion of toxic LPOs to nontoxic lipid alcohols
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Antioxidant Properties: It possesses the ability to combat oxidative stress, providing cellular protection
In targeted therapy, GSH depletion prevents redox-driven adaptive resistance to PI3K/AKT/mTOR, MAPK, and KRAS inhibitors, intensifying oxidative stress and restoring drug sensitivity
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