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Greater insulin release with exendin-phe1 was unlikely to result from cross-reactivity with other incretin receptors, as it was blocked with the GLP-1R orthosteric antagonist exendin(9-39) (Supplementary Fig
doi: 10.1186/s12890-021-01422-9 292 WestA
doi: 10.1002/ps.6713
Retatrutide produced the largest weight loss of the class up to ~24.2% at 48 weeks in Phase 2 so the absolute amount of lean mass lost can be larger simply because total loss is larger
It will offer a glimpse into the future as key trends play out that will shape how obesity is viewed, diagnosed and treated, while healthcare systems grapple with this formidable challenge
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