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Last, Retatrutide is a glucagon receptor agonist
Once you come off a GLP-1 medication like semaglutide or tirzepatide, your body may go through a few changes
IGF-1 Upregulates Biglycan and Decorin by Increasing Translation and Reducing ADAMTS5 [PMID: 33573338] Laboratory literature summary: IGF-1 Upregulates Biglycan and Decorin by Increasing Translation and Reducing ADAMTS5 Expression
Patients were randomized in a 5:1:1 ratio to either WEGOVY 7.2 mg, WEGOVY 2.4 mg or placebo once weekly
Organ Growth Concerns at High Doses Because IGF-1 acts on all tissue not just muscle megadosing for extended periods may promote organ tissue hypertrophy, including intestinal walls and heart tissue
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