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The long-term weight loss effect of GLP-1RAs has also been validated in a recent large-scale clinical trial, which reported a weight loss up to 20.9% after 72-week treatment of tirzepatide [22]

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In one analysis, about 3% of patients had a diagnosis of muscle loss within one year of starting a GLP-1 RA

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The official site displays examples of individual patients reporting different amounts of weight loss over different time periods