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As result, the blockage of NP into the nucleus dramatically affects viral packaging and final maturation (Nencioni et al., 2009)

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In hereditary or acquired metabolic defects, an initial intravenous bolus of 50 mg/kg may be administered over two to three minutes, followed by maintenance doses of 50 mg/kg every six hours or continuous infusion to achieve a total daily exposure of up to 300 mg/kg in critical illness

Semaglutide should be stored in a refrigerator at a temperature between 36F and 46F (2C and 8C)