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That triple mechanism produced up to 28.7% body weight reduction in Phase 3 trials, numbers that stunned even the researchers who designed the study

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GLP-1 receptors are abundant in brain regions controlling appetite, reward, and metabolic regulation, including the hypothalamus, brainstem, and nucleus tractus solitarius

15 demonstrating powerful inhibition of food intake after ICV administration of GLP-1, an effect that could be blocked by the specific receptor antagonists exendin 939, which also enhanced spontaneous as well as neuropeptide Y-stimulated food intake

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