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Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans
A phase II clinical trial (NCT03163667) indicated that CB-839 and mTOR inhibitor (everolimus) showed good tolerability and improved progression-free survival in patients when treating advanced clear cell renal cell carcinoma (ccRCC) (Lee et al., 2022)
Nutrition: Keep protein intake adequate and overall diet balanced to support metabolism and lean mass
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