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DKD is characterized by intestinal barrier dysfunction (leaky gut) and metabolic endotoxemia, creating a vicious cycle that sustains systemic inflammation and kidney injury

Therefore, inhibition of GSH biosynthesis via ACTL6A ablation promotes the induction of ferroptosis and sensitizes cells to oxidative stress

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During fasting, AMPK activation stimulates sirtuin 1 (SIRT1), which deacetylates and activates transcriptional coactivator PGC1 (48, 49)

Unfortunately, glutathione is not absorbed well by the body after oral administration, limiting its clinical use in humans