pfizer oral glp 1 Pfizer's Appetite for More Obesity Meds Leads to $150M Deal for GLP-1 Drug From China Pfizer Advances Oral GLP-1 Development

Supplied as white to off-white lyophilized powder, water-soluble, stored refrigerated at 28 C

Compounded medications are rarely covered by insurance but cost less than most insurance copays and can be purchased with HSA/FSA funds

PMID: 33524359

Rather than conducting a new meta-analysis, the authors synthesize findings from major randomized clinical trials, highlighting outcomes related to glycated hemoglobin (HbA1c), body weight reduction, major adverse cardiovascular events (MACE), and kidney function decline as reported in large cardiovascular outcomes trials (CVOTs), obesity randomized controlled trials, and early-phase clinical development studies

A 2020 meta-analysis in Clinical Nutrition ESPEN (Asbaghi et al.) pooled 12 randomized controlled trials and found that oral berberine reduced body weight by 2.07 kg and BMI by 0.47 kg/m2 versus control