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2 Gradual dose titration You start low and increase on a schedule your provider controls

The medication reaches steady state By week four or five, semaglutide achieves steady-state pharmacokinetics

Direct medication costs (approximate, 2026): Brand-name Wegovy: $1,400 per month ($16,800 per year) Compounded semaglutide: $250 to $400 per month ($3,000 to $4,800 per year) With insurance coverage: $25 to $50 per month ($300 to $600 per year) Indirect costs of regain: Weight regain after discontinuation carries health costs that are harder to quantify but real: Increased risk of type 2 diabetes (if weight returns to pre-treatment level, diabetes risk returns to baseline) Increased cardiovascular risk (weight loss on GLP-1 agonists reduces cardiovascular events

More often than not, patients reveal something unexpected

However, initial supply shortages have even led to the emergence of a "gray market" for compounded semaglutide