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Additionally, treatment with GLP-1RAs was found to upregulate the expression of pulmonary surfactant proteins A and B, contributing to improved respiratory physiology (Wang et al., 2023b)
While these effects are generally manageable, they represent more pronounced GI side effects than observed with AOD-9604
And the program has to do with the coordination of many different genes, and these master regulator transcription factors are part of that process