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The lens epithelium is particularly sensitive to oxidative stress, and oxidative damage of this layer of cells can result in the formation of lens opacities (Carper 1999

Concerns about the potential association between certain diabetes medications and cardiovascular disease meant that in 2010 the FDA approved liraglutide on condition that Novo Nordisk conduct a post-marketing study to evaluate the drug's effect on the incidence of major cardiovascular events (Nielsen, DeChiaro, Goldman)

Conclusion The potential for GLP-1 RAs to serve as a therapeutic option in AS presents an exciting avenue for further exploration, particularly given the unmet need for treatments that slow the progression of kidney function decline in this patient population

Pauly DF, Pepine CJ

Secher, Jelsing, Baqueror)