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Hyperpigmentation happens when small areas of skin make too much melanin, forming age spots, melasma, or postinflammatory marks

Henein MY, Vancheri S, Longo G, Vancheri F

Gudbergsen H, Henriksen M, Waehrens EE, Overgaard A, Bliddal H, Christensen R, Boesen MP, Knop FKK, Astrup A, Rasmussen MU, Bartholdy C, Daugaard C, Bartels EM, Ellegaard K, Heitmann BL, Kristensen LE (2019) Effect of liraglutide on body weight and pain in patients with overweight and knee osteoarthritis: protocol for a randomised, double-blind, placebo-controlled, parallel-group, single-centre trial

This likely occurs in later stages of the disease when renal function is affected (25)

Her improved numbers on the NASA lean test suggested her brain was getting more blood flows