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These building blocks are three amino acids: cysteine, glycine, and glutamate
Collectively, these mechanistic insights highlight the feasibility of multi-targeted therapeutic approaches that concurrently address metabolic abnormalities, inflammation, and fibrosis
Disruption of proteostasis is now recognized as a core pathological mechanism across cardiomyopathies, ischemic heart disease, arrhythmias, and heart failure, linking molecular protein quality control failure to tissue remodeling and clinical disease progression
GSDMA, GSDMB, GSDMC, GSDMD, GSDME, and DFNB59 are the six members of the GSDM protein family (127)
Growth hormone promotes lipolysis (fat breakdown) and shifts metabolism toward preferential use of fat for energy
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