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The vast majority of weight loss, over 90 percent of the total, occurs within the first 12 months
In the self-controlled case series design, use of GLP-1 RAs was associated with a lower incidence rate ratio (IRR) of suicide or suicide attempts one year after treatment initiation (IRR: 0.45
These symptoms are not part of normal treatment adjustment and should never be ignored
The results indicate that there is a minor delay of gastric emptying during the early postprandial phase for subjects when treated with semaglutide, compared with placebo, but there is no overall effect on gastric emptying over a 5-h postprandial period [13]
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