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Studies show that activation of the GLP-1 receptor in the brain reduces dopamine release from addictive substances such as nicotine and alcohol, leading to fewer cravings and reinforcement

The study compares tirzepatide with the long-acting GLP-1 RA, dulaglutide for non-inferiority and superiority, and is currently in progress [61]

Freezing a reconstituted peptide solution is not recommended, because the freeze-thaw cycle can cause aggregation and denaturation that reduces potency

To help maintain stability and peptide integrity, repeated freeze-thaw cycles should be avoided