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Pathophysiological processes where melatonin plays important roles Antiapoptotic activity Almost all the studies that monitored the melatonin-dependent antiapoptotic activities include disease models characterized by the presence of a hypoxicischemia (HI) event

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Here, we show that culturing lymphoid cells in 3D gels triggers reactive oxygen species (ROS) production, leading to non-tumor lymphoid cell death while enabling the survival and proliferation of a subset of lymphoma/leukemia cells, TICs or TIC-like cells