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Study 3: Combination With Diet Independent work showed that NNMT inhibition plus a lean/low-fat diet accelerated weight and fat loss beyond diet alone, improved the lean-mass-to-body-weight ratio, and ameliorated obesity-linked liver pathologies

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Using tert-Butyl hydroperoxide (t-BHP), a ROS-inducer, NRF2 was activated and stabilized, and the GCLC expression was significantly upregulated correspondingly (Fig