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Pregnant and breastfeeding women, people with known allergies to glutathione, and those taking specific medications may also need to avoid treatment

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Its not clear how semaglutide affects this issue long-term

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Yang PY, Zou H, Lee C, Muppidi A, Chao E, Fu Q, Luo X, Wang D, Schultz PG, Shen W (2018) Stapled, long-acting glucagon-like peptide 2 analog with efficacy in dextran sodium sulfate induced mouse colitis models