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To establish connection with the NO-system, L-NAME (5.0 mg/kg) (worsening) and L-arginine (200.0 mg/kg) (effective only with blunted NO-synthesis, but not alone) were given intraperitoneally alone or in combination (d-arginine 200.0 mg/kg was not effective, data not shown)

Published mouse studies did not report overt toxicity, liver-enzyme issues, or sickness-related weight loss at 25-50 mg/kg IP for up to 8 weeks

A deficiency of glutathione puts the cell at risk for oxidative damage

That longer action is part of why maintenance injections can be spaced months apart rather than weeks

It can offer large utility for patients who struggle with ailments such as those with AIDS or cystic fibrosis