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However, the compound with a cyclopropylmethyl group at the N 7 -position demonstrated poor microsomal stability, prompting structural optimization at the N 2 -position to improve metabolic stability

Oral bioavailability of GLP-1RAs with permeation enhancers in vivo Male Sprague Dawley rats (Charles River, Shrewsbury, MA, USA) weighing 250275 g were housed with ad libitum access to standard chow and water

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Second, publication bias toward positive findings and underreporting of negative or null results may further influence interpretations of GLP-1 RA efficacy

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