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Orforglipron dose was increased every four weeks until maximum tolerated dose (MTD) or 36 mg, and this was continued until the end of the 52-week study
the separate TRIUMPH-Outcomes cardiovascular and kidney outcomes trial accounts for about 10,000 more
Its use is ideal for curbing cravings and adopting better meal management
Research published in Nature Reviews Endocrinology and other medical journals indicates that early studies suggest GLP-1 medications may reduce cravings for substances such as alcohol, nicotine, and highly processed foods
But preclinical studies also suggest GLP-1RAs may also work as an anti-inflammatory, potentially calming immune responses that trigger swelling and tissue damage
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