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The members of the neurotrophin family of growth factors, such as BDNF and NGF, play essential roles in the development of the nervous system, as they support the survival, growth, and maintenance of neurons in the brain [229]

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Less common reactions include contact dermatitis (a rash or itching that doesnt resolve), persistent redness, or a localized copper reaction

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doi: 10.1016/j.cell.2011.10.026 77 ParzychKRKlionskyDJ