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The NAC and placebo arms were stratified according to clinical parameters listed in Table 1A, and did not differ between groups, except for maternal pre-gravid BMI, which was slightly higher in the NAC arm in severe IPTB cases (Supplementary Table S2)
Meanwhile, the cumulative excretion amounts of M3, M4, and M5 were less than 0.014% in the urine and 0.1% in the bile, compared with 0.039 0.041%, 0.26 0.24%, and 0.69 0.46% for M3, M4, and M5 in the feces, respectively
La dosis se aumenta gradualmente en incrementos de 2.5 mg cada 4 semanas segn la respuesta clnica y tolerabilidad, hasta alcanzar dosis de mantenimiento de 5-15 mg semanales
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