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(2018) conducted a double-blind, placebo-controlled trial demonstrating that high-dose folinic acid improved verbal communication, attention, and stereotypical behaviors in children with ASD and FR autoantibodies
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54 Some have hypothesized that abnormalities in zinc and copper metabolism could result in poor metallothionein function, leading to susceptibility to environmental toxicants through increased oxidative stress or mitochondrial dysfunction
Notable limitations of this retrospective study include potential patient selection bias, as only 316 of the 14,606 patients on GLP-RAs were included due to availability of GUS images
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