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Similarly, tirzepatide, a dual GLP-1R and GIP receptor agonist, does not seem to cross the BBB efficiently (Rhea et al., 2024)

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And importantly, clinicians should remain open to considering rare diagnoses like ROHHAD when the phenotype includes hypoventilation, autonomic dysregulation, or extreme hyperphagia. Perhaps one of the most exciting takeaways is that this patients hyperphagia improved markedly (and likewise quickly worsened during medication interruptions), suggesting that some of her hyperphagia was being modulated by GLP-1 RA therapy