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Institutions need to establish clear, evidence-informed protocols around when to discontinue GLP-1 drugs prior to various types of surgery, how to bridge diabetes therapy, and who to engage
These CAFs uptake OxLDL and activate the PPARG-FABP4 axis, leading to ANGPTL4 secretion that promotes CD8+ T cell exhaustion
Clinical trials with semaglutide have demonstrated significant reductions in liver fat content and encouraging rates of MASH resolution, reinforcing the concept that metabolic therapies may fundamentally reshape the future management of chronic liver disease
C., Del Boccio, G., Aceto, A
Including patients with Alport syndrome in general CKD treatment trials offers benefits such as larger sample sizes, cost-efficiency, and faster access to results, given shared disease mechanisms with many of the CKD etiologies
