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The observed 28-day mortality was 42.9% (12 patients), 8 patients died in less than 72 h

This may identify the so-called parallel or non-parallel healing actions, with the final end result, positive (fistula closing) or negative (fistula remains open) (Skorjanec et al., 2009)

[] When the impact of NAC on biochemical indicators of inflammatory processes was further examined, blood levels of C-reactive protein (CRP), tumour necrosis factor-alpha, IL-10, IL-6, IL-8 and brain-derived neurotrophic factor (BDNF) showed no significant changes

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