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Lack of rest increases cortisol and ghrelin, the same hormones that drive appetite
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Its Phase 2 weight loss data (24.2% at 48 weeks) and mechanistic advantages in hepatic fat reduction through glucagon receptor activation suggest it could surpass semaglutide's efficacy if Phase 3 results confirm the Phase 2 findings
The GIP receptor activation in tirzepatide also affects appetite regulation differently than single GLP-1 therapy, sometimes causing more pronounced food aversion in the first 2-4 weeks
By week 8, average weight loss is around 4%, though this varies from person to person
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