One more clinical note: the trial used a gradual titration protocol specifically to manage tolerability
While other pharmacological Nrf2 activators (e.g., sulforaphane, bardoxolone methyl, curcumin, dimethyl fumarate, and various phytochemicals) directly stabilize Nrf2 to promote transcription of cytoprotective genes, ozones action involves transient redox signaling that indirectly activates Nrf2 alongside other stress-responses (Bocci and Valacchi 2015)
Presented for research literature review only Shaw AJ et al
PPAR plays a crucial role in regulating fatty acid oxidation, lipid metabolism, and glucose homeostasis (37)
Interestingly, while the weights of four different skeletal muscles were measured, no significant changes were observed, although a trend toward decreased muscle mass was noted