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Conclusion In summary, the core mechanistic and design principles for effective probiotic nanocarriers revolve around robust protection against gastrointestinal barriers (e.g., pH-responsive release and biomimetic coatings for enhanced survival and mucosal adhesion), stimulus-triggered metabolite production (e.g., SCFAs for immune modulation via GALT interactions, Treg differentiation, and M2 macrophage polarization), and platform-specific tunability to balance biocompatibility, targeting, and safety

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It is studied for aging signals, growth hormone release, sleep-related markers, and cellular repair pathways