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Whilst feeling cold is not listed as a recognised adverse effect in the MHRA-approved Summary of Product Characteristics, some patients report increased cold sensitivity whilst taking this medication

In TE, the follicle goes into rest mode, not permanent shutdown

The article says both cause nausea, vomiting, and diarrhea, that these effects are dose-dependent and often improve with time, and that tirzepatide's dual receptor activation may make them slightly more frequent while a strength is being raised