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Causes of Excessive B12 Levels Elevated serum vitamin B12 levels (hypercobalaminaemia) can arise from various mechanisms, both iatrogenic and pathological
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Vitamin B 6 , folate, and vitamin B 12 regulate the amount of circulating homocysteine (see Figure 1 above), and a deficiency of any of these B vitamins can lead to hyperhomocysteinemia, a condition treated through B vitamin supplementation
and treatment with sulforaphane, a dietary antioxidant, activates Nrf2 and suppresses p38VCAM-1 signaling, and may provide a novel therapeutic strategy to prevent or reduce atherosclerosis (237)