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Tirzepatide, compared to both GLP-1 and NNC0090-2746, shows biased signaling at GLP-1R, favoring cAMP response over -arrestin recruitment, which leads to low efficacy for GLP-1R internalization (108110)
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So yes, you can influence GLP-1 through food, movement, and lifestyleespecially if youre also using medication
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