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No cases meeting Hy's Law criteria (ALT/AST elevation greater than 3 times ULN combined with bilirubin elevation greater than 2 times ULN) have been reported
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More important than concentration is the formulation's pH stability (GHK-Cu is stable between pH 5.0 and 6.5) and the carrier's ability to deliver the peptide past the skin barrier
Tkalcevic et al., 2007
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